The only difference is if you want to use a network MIDI connection. Mac's have network MIDI built-in and you can set it up with the Audio Midi Setup application. For PC's, there is a third party application,
rtpMIDI, that may provide this capability (see the bottom of the rsRemote “Requirements & Setup” page of this website). However PC users must also have Bonjour installed and working on the PC and network. Bonjour is part of the standard iTune's installation so if you have skipped that you will need to install Bonjour yourself.